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      I.         Overview of proposed key changes The Swiss Federal Act on Medicinal Products and Medical Devices (Swiss Therapeutic Products Act, TPA), which has been in force since 2002, is currently undergoing its third revision. The proposed changes are designed to improve the safety and quality of medicinal products and medical devices (therapeutic products). The […]

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**Cauliflower Salad from Bar Tartine: A Culinary Delight**

Bar Tartine, a renowned restaurant in San Francisco, is celebrated for its innovative approach to traditional dishes, and its cauliflower salad is no exception. This dish exemplifies the restaurant’s commitment to creating vibrant, flavorful, and health-conscious meals using fresh, locally sourced ingredients.

**The Essence of Bar Tartine’s Cauliflower Salad**

At the heart of this salad is the cauliflower, a versatile vegetable that serves as a blank canvas for a myriad of flavors. Bar Tartine elevates this humble ingredient by roasting it to perfection, enhancing its natural sweetness and adding a delightful crispness. The roasting process also imparts a subtle smokiness, which forms the foundation of the salad’s complex flavor profile.

**Ingredients and Preparation**

The cauliflower salad at Bar Tartine is a symphony of textures and tastes. Alongside the roasted cauliflower, the salad typically includes a mix of fresh herbs such as parsley and dill, which add a refreshing brightness. Nuts and seeds, often toasted almonds or sunflower seeds, contribute a satisfying crunch, while dried fruits like currants or raisins introduce a touch of sweetness.

A key component of the salad is its dressing, which ties all the elements together. The dressing is usually a tangy vinaigrette, made with ingredients like lemon juice, olive oil, and a hint of garlic. This dressing not only enhances the flavors of the individual components but also ensures a harmonious blend of tastes in every bite.

**Nutritional Benefits**

Cauliflower is a nutritional powerhouse, rich in vitamins C and K, fiber, and antioxidants. The inclusion of nuts and seeds adds healthy fats and protein, making the salad a well-rounded, nutritious option. The use of fresh herbs not only boosts flavor but also provides additional vitamins and minerals.

**Culinary Influence and Philosophy**

Bar Tartine’s approach to the cauliflower salad reflects its broader culinary philosophy: a dedication to craftsmanship, a respect for ingredients, and a passion for innovation. The restaurant draws inspiration from diverse culinary traditions, incorporating techniques and flavors from Eastern European, Middle Eastern, and Mediterranean cuisines.

**Conclusion**

The cauliflower salad from Bar Tartine is more than just a dish; it’s an experience that captures the essence of the restaurant’s inventive spirit. By transforming simple ingredients into a sophisticated and satisfying meal, Bar Tartine continues to delight diners with its creative culinary offerings. Whether you’re a local or a visitor to San Francisco, this salad is a must-try for anyone seeking a taste of the restaurant’s exceptional cuisine.

**Crab-Stuffed Flounder with Corn and Zucchini: A Beloved Summer Recipe**

Crab-stuffed flounder with corn and zucchini is a charming seafood creation that embodies the spirit of summer dining. This meal merges the subtle tastes of flounder with the sweetness of crab meat and the freshness of seasonal produce, establishing it as a favorite for seafood enthusiasts.

**Ingredients and Preparation**

The main elements of this dish consist of flounder fillets, fresh crab meat, corn, zucchini, along with a mix of herbs and spices. The process starts with the flounder, which is generally filleted and dried. The crab meat is frequently combined with sautéed corn and zucchini, breadcrumbs, garlic, lemon juice, and fresh herbs such as parsley or dill. This combination is then placed onto the flounder fillets, which are rolled or folded over the filling and secured with toothpicks or kitchen twine.

**Cooking Methods**

Crab-stuffed flounder can be made using different cooking techniques, such as baking, grilling, or pan-searing. Baking is a favored option as it allows the flavors to blend while keeping the fish moist. When baked, the dish is often garnished with a drizzle of olive oil and a dusting of paprika for enhanced taste and visual appeal. Cooking durations differ based on the method, but the dish is generally ready when the fish is opaque and flakes effortlessly with a fork.

**Flavor Profile**

The blend of sweet crab meat, tender flounder, and the earthy tones of corn and zucchini creates a pleasing equilibrium. The addition of lemon juice elevates the dish, while herbs contribute freshness. This ensemble of flavors makes it an ideal selection for summer festivities, barbecues, or a light family meal.

**Nutritional Benefits**

Crab-stuffed flounder is not only tasty but also healthful. Flounder is a low-calorie fish that is high in protein and omega-3 fatty acids, which are advantageous for cardiovascular health. Crab meat also serves as a rich protein source and is packed with essential vitamins and minerals. The addition of corn and zucchini brings fiber, vitamins A and C, and antioxidants, rendering this dish a nutritious option for a well-rounded meal.

**Serving Suggestions**

This dish pairs best with a light side salad or steamed vegetables to enhance the flavors. A chilled white wine, such as Sauvignon Blanc or Chardonnay, complements the seafood, improving the dining experience. For a more relaxed atmosphere, serve the flounder with crusty bread to soak up any remaining juices.

**Conclusion**

Crab-stuffed flounder with corn and zucchini is a flexible and enticing dish that highlights the finest of summer’s harvest. Its combination of flavors, health benefits, and straightforward preparation makes it a sought-after choice for both home cooks and culinary professionals. Whether savored at a summer gathering or a warm family dinner, this meal is sure to delight and fulfill.

**Refreshing Miso Soup with a Spicy Twist for Summer**

As the summer sun blazes, our culinary cravings often shift towards lighter, more refreshing meals. Miso soup, a staple in Japanese cuisine, is traditionally a warm, comforting dish. However, with a few creative tweaks, it can be transformed into a refreshing summer delight with a spicy twist. This version of miso soup not only satisfies the palate but also invigorates the senses, making it an ideal choice for a summer meal.

**The Base: Traditional Miso Soup**

At its core, miso soup is a simple concoction of dashi (a Japanese soup stock) and miso paste. Dashi is typically made from kombu (dried kelp) and bonito flakes, providing a rich umami flavor. Miso paste, made from fermented soybeans, adds depth and a slightly salty taste. This combination forms a savory base that can be adapted with various ingredients to suit different seasons and preferences.

**Adding a Spicy Twist**

To give miso soup a spicy kick, consider incorporating ingredients that add both heat and freshness. Here are some suggestions:

1. **Chili Oil or Paste**: A drizzle of chili oil or a spoonful of spicy chili paste can instantly elevate the soup’s flavor profile. Adjust the amount based on your heat tolerance.

2. **Fresh Ginger**: Adding thin slices of fresh ginger not only introduces a zesty note but also complements the soup’s umami base. Ginger is known for its digestive benefits, making it a great addition for a summer dish.

3. **Sriracha or Hot Sauce**: For those who enjoy a tangy heat, a splash of sriracha or your favorite hot sauce can do wonders. It adds a layer of complexity and a vibrant color to the soup.

4. **Spicy Peppers**: Thinly sliced jalapeños or serrano peppers can be added for a fresh, spicy crunch. These peppers also provide a visual appeal with their bright green hue.

**Refreshing Ingredients for Summer**

To balance the spiciness and make the soup more refreshing, incorporate seasonal ingredients that are light and hydrating:

– **Cucumber**: Adding thinly sliced cucumber can provide a cooling contrast to the heat. Its crisp texture and subtle flavor blend seamlessly with the soup.

– **Tofu**: Soft or silken tofu is a classic addition to miso soup. It absorbs the flavors of the broth while offering a creamy texture that complements the spice.

– **Seaweed**: Wakame seaweed is a traditional ingredient in miso soup. Its slightly sweet and briny taste enhances the overall flavor, while its soft texture contrasts with the crunchy elements.

– **Fresh Herbs**: Garnishing the soup with fresh herbs like cilantro or mint can add a refreshing aroma and a pop of color.

**Serving Suggestions**

For a complete summer meal, serve the spicy miso soup with a side of chilled soba noodles or a light salad. Pair it with a cold beverage, such as iced green tea or a citrus-infused water, to further enhance the refreshing experience.

**Conclusion**

Refreshing miso soup with a spicy twist is a delightful way to enjoy a traditional dish during the warmer months. By incorporating spicy elements and fresh, seasonal ingredients, this version of miso soup becomes a vibrant and invigorating meal. Whether served as a starter or a main course, it promises to tantalize the taste buds and provide a satisfying culinary experience.

**Sizzling Summer: The Best Cookbooks for Refreshing Seasonal Recipes**

As the sun shines brighter and the days grow longer, summer invites us to explore vibrant flavors and fresh ingredients. Whether you’re planning a backyard barbecue, a picnic in the park, or a light dinner on the patio, the right cookbook can be your perfect companion. Here’s a look at some of the best cookbooks that capture the essence of summer cooking.

**1. “Plenty” by Yotam Ottolenghi**

Yotam Ottolenghi’s “Plenty” is a celebration of vegetables, making it ideal for summer when produce is at its peak. The book features a variety of Mediterranean-inspired dishes that are both colorful and flavorful. Recipes like Eggplant with Buttermilk Sauce and Saffron Cauliflower are perfect for light, refreshing meals.

**2. “The Beach House Cookbook” by Mary Kay Andrews**

Mary Kay Andrews brings the spirit of coastal living to your kitchen with “The Beach House Cookbook.” This collection is filled with easy-to-make recipes that are perfect for summer gatherings. From Lowcountry Boil to Key Lime Pie, each dish is designed to be enjoyed with family and friends by the sea or in your backyard.

**3. “Six Seasons: A New Way with Vegetables” by Joshua McFadden**

Joshua McFadden’s “Six Seasons” offers a unique approach to seasonal cooking, highlighting the best of summer produce. The book is organized by season and provides innovative ways to use vegetables. Summer recipes like Corn and Tomato Salad with Torn Croutons and Zucchini with Parmesan are sure to become staples in your kitchen.

**4. “Weber’s Big Book of Grilling” by Jamie Purviance**

For those who love to grill, “Weber’s Big Book of Grilling” by Jamie Purviance is a must-have. This comprehensive guide covers everything from burgers and steaks to grilled vegetables and seafood. With tips on grilling techniques and a variety of marinades and rubs, you’ll be ready to impress at your next cookout.

**5. “The Summer Table: Recipes and Menus for Casual Outdoor Entertaining” by Lisa Lemke**

Lisa Lemke’s “The Summer Table” is perfect for those who enjoy dining al fresco. The book offers a range of recipes and complete menus tailored for outdoor entertaining. Dishes like Grilled Chicken with Mango Salsa and Raspberry Lemonade are sure to delight guests and make any summer gathering memorable.

**6. “Salad for President: A Cookbook Inspired by Artists” by Julia Sherman**

Julia Sherman’s “Salad for President” brings creativity to the table with its art-inspired salads. The book features a variety of unique salad recipes that are perfect for summer, such as Grilled Peach and Burrata Salad and Watermelon Radish with Avocado. It’s a great choice for those looking to add a touch of artistry to their meals.

**7. “The New Vegetarian Cooking for Everyone” by Deborah Madison**

Deborah Madison’s classic, “The New Vegetarian Cooking for Everyone,” offers a wealth of vegetarian recipes that are ideal for summer. With an emphasis on fresh ingredients and simple preparations, dishes like Summer Squash Soup and Tomato and Basil Tart make the most of seasonal produce.

**Conclusion**

These cookbooks offer a diverse array of recipes that capture the essence of summer. Whether you’re a fan of grilling, love fresh salads, or enjoy experimenting with seasonal vegetables, there’s something for everyone. So grab a cookbook, head to your local farmer’s market, and start creating delicious summer dishes that will keep you cool and satisfied all season long.

**Toasted Bread with Deviled Egg Spread: A Classic Delight**

Toasted bread with deviled egg spread is a timeless culinary combination that brings together the satisfying crunch of perfectly toasted bread and the creamy, tangy richness of deviled eggs. This dish is not only a favorite for breakfast or brunch but also makes for a delightful appetizer or snack. Here, we explore the origins, preparation, and variations of this classic dish.

**Origins and History**

The concept of deviled eggs dates back to ancient Rome, where boiled eggs were seasoned with spicy sauces. The term “deviled” became popular in the 18th century to describe foods that were spicy or zesty. Over time, deviled eggs evolved into the beloved appetizer we know today, typically featuring a filling of egg yolks mixed with mayonnaise, mustard, and various seasonings.

Toasted bread, on the other hand, has been a staple in many cultures for centuries. The process of toasting bread enhances its flavor and texture, making it an ideal base for a variety of toppings.

**Preparation**

To create toasted bread with deviled egg spread, start by preparing the deviled egg mixture. Boil eggs until they are hard-cooked, then peel and halve them. Remove the yolks and mash them in a bowl, combining them with mayonnaise, mustard, vinegar, salt, and pepper. For added flavor, consider incorporating ingredients like paprika, dill, or chives.

Next, prepare the bread. Choose a hearty loaf such as sourdough, whole grain, or baguette. Slice the bread and toast it until golden brown. The toasting process can be done using a toaster, oven, or stovetop, depending on your preference.

Once the bread is toasted, generously spread the deviled egg mixture over each slice. The creamy spread contrasts beautifully with the crisp texture of the toast, creating a harmonious blend of flavors and sensations.

**Variations**

Toasted bread with deviled egg spread is highly versatile, allowing for numerous variations to suit different tastes:

1. **Spicy Kick**: Add a dash of hot sauce or finely chopped jalapeños to the deviled egg mixture for a spicy version.

2. **Herb-Infused**: Mix in fresh herbs like parsley, tarragon, or basil for a fragrant twist.

3. **Bacon Bliss**: Top the spread with crumbled bacon for an extra layer of savory goodness.

4. **Avocado Addition**: Incorporate mashed avocado into the deviled egg mixture for a creamy, nutrient-rich option.

5. **Pickle Perfection**: Add finely chopped pickles or relish for a tangy, crunchy contrast.

**Serving Suggestions**

Toasted bread with deviled egg spread can be served as an elegant appetizer at gatherings or as a comforting breakfast option. Pair it with a fresh salad or a bowl of soup for a complete meal. For a visually appealing presentation, garnish with a sprinkle of paprika or a sprig of fresh herbs.

**Conclusion**

Toasted bread with deviled egg spread is a delightful dish that combines simplicity with sophistication. Its rich history and adaptability make it a cherished favorite across cultures. Whether enjoyed as a quick snack or a centerpiece at a brunch table, this classic combination is sure to please palates and bring a touch of culinary nostalgia to any occasion.

**7-Day Nutritious Meal Plan Free to Access (June 23-29)**

Eating well can be simple and affordable. To assist you in starting your health journey, we’ve prepared a 7-day nutritious meal plan that is not just healthy but also straightforward. This meal plan is available at no cost from June 23 to June 29, featuring a range of meals suitable for various dietary needs. Below is a comprehensive outline of the meal plan, detailing breakfast, lunch, dinner, and snacks for each day.

### Day 1: June 23
– **Breakfast:** Overnight oats prepared with almond milk, chia seeds, and assorted berries.
– **Lunch:** Quinoa salad featuring cherry tomatoes, cucumber, feta cheese, and a lemon dressing.
– **Dinner:** Grilled chicken breast served with steamed broccoli and sweet potatoes.
– **Snack:** A small handful of almonds.

### Day 2: June 24
– **Breakfast:** Smoothie consisting of spinach, banana, protein powder, and almond butter.
– **Lunch:** Turkey and avocado wrap using a whole grain tortilla with mixed greens.
– **Dinner:** Baked salmon accompanied by asparagus and brown rice.
– **Snack:** Carrot sticks paired with hummus.

### Day 3: June 25
– **Breakfast:** Greek yogurt topped with honey, walnuts, and sliced peaches.
– **Lunch:** Lentil soup served with a side of whole grain bread.
– **Dinner:** Stir-fried tofu with bell peppers, broccoli, and quinoa.
– **Snack:** Apple slices with peanut butter.

### Day 4: June 26
– **Breakfast:** Scrambled eggs with spinach and whole grain toast.
– **Lunch:** Chickpea salad with red onion, parsley, and a balsamic dressing.
– **Dinner:** Grilled shrimp tacos served with cabbage slaw and avocado.
– **Snack:** Celery sticks with cream cheese.

### Day 5: June 27
– **Breakfast:** Chia pudding made with coconut milk and topped with mango.
– **Lunch:** Chicken breast stuffed with spinach and feta, accompanied by roasted vegetables.
– **Dinner:** Zucchini noodles with marinara sauce and turkey meatballs.
– **Snack:** A small bowl of mixed berries.

### Day 6: June 28
– **Breakfast:** Whole grain pancakes topped with fresh strawberries and a drizzle of maple syrup.
– **Lunch:** Quinoa and black bean bowl featuring corn, avocado, and lime dressing.
– **Dinner:** Baked cod served with sautéed kale and quinoa.
– **Snack:** Greek yogurt sprinkled with granola.

### Day 7: June 29
– **Breakfast:** Smoothie bowl with acai, banana, topped with granola and coconut flakes.
– **Lunch:** Grilled vegetable and hummus wrap in a whole grain tortilla.
– **Dinner:** Stuffed bell peppers filled with ground turkey, brown rice, and spices.
– **Snack:** Dark chocolate square accompanied by a handful of walnuts.

### Tips for Achieving Success
– **Preparation:** Dedicate some time over the weekend to prepare ingredients, simplifying cooking throughout the week.
– **Hydration:** Consume plenty of water during the day to stay hydrated.
– **Portion Control:** Be attentive to portion sizes to maintain a balanced diet.
– **Flexibility:** Don’t hesitate to change meals or ingredients according to your tastes and dietary requirements.

This 7-day meal plan aims to offer balanced nutrition while making meals varied and flavorful. Savor the diversity and make the most of this free resource to improve your health and wellness!

On International Clinical Trials Day, the UK’s MHRA unveiled a major shift: a consultation on using external control arms (ECAs) based on real-world data (RWD) for regulatory decisions. This move aims to leverage patient-level data collected outside clinical studies to compare the efficacy and safety of interventions in clinical trials. Stakeholders have until the end […]

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**Homemade Pasta Shapes: A Fun Guide to Making Your Own**

Making pasta from scratch is a rewarding culinary adventure that allows you to explore a variety of shapes and textures. Whether you’re a seasoned chef or a kitchen novice, crafting homemade pasta can be both fun and satisfying. Here’s a guide to help you create your own pasta shapes at home.

**Basic Pasta Dough Recipe**

Before diving into shapes, you’ll need a basic pasta dough. Here’s a simple recipe:

– **Ingredients:**
– 2 cups all-purpose flour
– 3 large eggs
– A pinch of salt
– 1 tablespoon olive oil (optional)

– **Instructions:**
1. On a clean surface, mound the flour and create a well in the center.
2. Crack the eggs into the well, add salt, and olive oil if using.
3. Gradually mix the flour into the eggs using a fork until a dough begins to form.
4. Knead the dough for about 8-10 minutes until smooth and elastic.
5. Wrap in plastic wrap and let it rest for at least 30 minutes.

**Popular Pasta Shapes to Try**

1. **Fettuccine**
– Roll out the dough into thin sheets.
– Use a sharp knife or a pasta cutter to slice into long, flat ribbons.
– Perfect for creamy sauces like Alfredo.

2. **Ravioli**
– Roll out two thin sheets of dough.
– Place small mounds of filling (cheese, meat, or vegetables) on one sheet.
– Cover with the second sheet and press around the filling to seal.
– Cut into squares or circles with a ravioli cutter.

3. **Farfalle (Bow Ties)**
– Roll out the dough and cut into small rectangles.
– Pinch the center of each rectangle to form a bow tie shape.
– Great for light tomato or pesto sauces.

4. **Orecchiette**
– Roll the dough into a long rope and cut into small pieces.
– Press each piece with your thumb to create a small, ear-like shape.
– Ideal for chunky vegetable or sausage sauces.

5. **Gnocchi**
– Although technically a dumpling, gnocchi is a delightful addition to your pasta repertoire.
– Combine mashed potatoes with flour and egg to form a dough.
– Roll into ropes, cut into pieces, and shape with a fork.

**Tips for Perfect Pasta**

– **Flour Choice:** For a more traditional pasta, use semolina flour or a mix of semolina and all-purpose flour.
– **Resting Time:** Allowing the dough to rest is crucial for gluten development, making it easier to roll out.
– **Rolling Techniques:** Use a pasta machine for uniform thickness, or a rolling pin for a more rustic feel.
– **Cooking:** Fresh pasta cooks quickly, usually in 2-4 minutes. Taste test for al dente texture.

**Conclusion**

Creating homemade pasta shapes is a delightful way to bring a touch of Italy into your kitchen. Experiment with different shapes and pair them with your favorite sauces for a truly personalized meal. Whether you’re making fettuccine or ravioli, the process is as enjoyable as the delicious results. So, roll up your sleeves, dust off your rolling pin, and start crafting your own pasta masterpieces today!

**Title: The Ultimate Guide to a Delicious and Nutritious Chickpea Salad Sandwich**

Sandwiches are a staple in many diets around the world, offering convenience, versatility, and endless possibilities for creativity. Among the myriad of sandwich options, the Chickpea Salad Sandwich stands out as a delicious, nutritious, and plant-based alternative to traditional meat-filled sandwiches. This article explores the components, benefits, and preparation of a Chickpea Salad Sandwich, making it a must-try for anyone looking to diversify their sandwich repertoire.

**The Chickpea Advantage**

Chickpeas, also known as garbanzo beans, are the star ingredient in this sandwich. They are a powerhouse of nutrition, rich in protein, fiber, vitamins, and minerals. Chickpeas are particularly high in folate, iron, phosphorus, and manganese, making them an excellent choice for those seeking a healthy and balanced diet. Their nutty flavor and creamy texture make them an ideal base for a salad filling.

**Ingredients for a Perfect Chickpea Salad Sandwich**

To create a Chickpea Salad Sandwich, you will need the following ingredients:

– **Chickpeas**: Canned or cooked from dry, mashed to a chunky consistency.
– **Vegetables**: Finely chopped celery, red onion, and bell peppers add crunch and flavor.
– **Herbs**: Fresh parsley or dill for a burst of freshness.
– **Binding Agent**: Vegan mayonnaise or Greek yogurt for creaminess.
– **Seasoning**: Salt, pepper, lemon juice, and a touch of Dijon mustard for tanginess.
– **Bread**: Whole grain, sourdough, or your favorite sandwich bread.

**Preparation Steps**

1. **Mash the Chickpeas**: Drain and rinse the chickpeas if using canned. Use a fork or potato masher to mash them in a bowl, leaving some chunks for texture.

2. **Mix the Ingredients**: Add the chopped vegetables, herbs, and binding agent to the mashed chickpeas. Stir in the lemon juice, mustard, salt, and pepper. Mix until well combined.

3. **Assemble the Sandwich**: Toast the bread slices if desired. Spread a generous amount of the chickpea salad on one slice of bread. Top with leafy greens, tomato slices, or avocado for added nutrition and flavor. Place the second slice of bread on top.

4. **Serve and Enjoy**: Cut the sandwich in half and serve with a side of fresh fruit, salad, or soup for a complete meal.

**Health Benefits**

The Chickpea Salad Sandwich is not only delicious but also offers numerous health benefits:

– **Plant-Based Protein**: Chickpeas provide a substantial amount of protein, essential for muscle repair and growth.
– **Fiber-Rich**: The high fiber content aids digestion and promotes a feeling of fullness, which can help with weight management.
– **Heart Health**: The combination of chickpeas and vegetables contributes to heart health by lowering cholesterol levels and reducing the risk of heart disease.
– **Vegan-Friendly**: This sandwich is an excellent option for vegans and vegetarians, offering a satisfying and nutritious meal without animal products.

**Conclusion**

The Chickpea Salad Sandwich is a versatile and nutritious option that can be enjoyed by everyone, regardless of dietary preferences. Its simple preparation, combined with the health benefits of chickpeas and fresh vegetables, makes it a perfect choice for a quick lunch, picnic, or light dinner. Whether you’re a seasoned plant-based eater or new to the world of chickpeas, this sandwich is sure to become a favorite in your culinary repertoire.