HEALTHONLINEUS

**Amy Schumer and Connie Britton Participate in Midi Health’s $63M Series B Funding Round: A Major Step Forward for Women’s Healthcare**

In a significant move that underscores the growing importance of women’s health in the tech and healthcare sectors, comedian and actress Amy Schumer and actress Connie Britton have joined forces with other investors to support Midi Health, a digital health platform focused on menopause care. The company recently announced the successful completion of a $63 million Series B funding round, signaling a major step forward in addressing the often-overlooked healthcare needs of women in midlife.

### **Midi Health: A New Era in Menopause Care**

Midi Health is a digital health startup that aims to revolutionize the way women experience and manage menopause. Founded by a team of healthcare professionals and technologists, the company offers personalized, evidence-based care for women going through perimenopause and menopause. Through a combination of telemedicine, data-driven insights, and expert consultations, Midi Health provides a comprehensive approach to managing the physical, emotional, and psychological challenges that come with this stage of life.

Menopause, a natural biological process that marks the end of a woman’s reproductive years, affects millions of women globally. Yet, it remains an under-discussed and under-researched area in healthcare. Symptoms such as hot flashes, mood swings, sleep disturbances, and cognitive changes can significantly impact a woman’s quality of life, but many women struggle to find adequate care and support. Midi Health aims to fill this gap by offering accessible, high-quality care tailored to individual needs.

### **Amy Schumer and Connie Britton: Advocates for Women’s Health**

Amy Schumer and Connie Britton are no strangers to advocating for women’s issues. Schumer, known for her candid humor and outspoken advocacy on topics like body image, reproductive rights, and mental health, has increasingly used her platform to raise awareness about women’s healthcare challenges. In 2022, Schumer publicly discussed her own struggles with endometriosis, a painful condition affecting the uterus, which led her to undergo surgery. Her involvement in Midi Health aligns with her broader mission to break taboos around women’s health and ensure that women receive the care they deserve.

Connie Britton, an Emmy-nominated actress best known for her roles in *Friday Night Lights* and *Nashville*, has long been an advocate for gender equality and women’s empowerment. She has worked with organizations like the United Nations Development Programme (UNDP) to promote women’s rights globally. By investing in Midi Health, Britton is furthering her commitment to improving the lives of women, particularly in areas where healthcare has historically fallen short.

Both Schumer and Britton’s participation in the funding round not only brings financial support to Midi Health but also shines a spotlight on the critical need for better healthcare solutions for women in midlife. Their involvement is likely to raise awareness about menopause and encourage more women to seek the care they need.

### **The $63 Million Series B Funding Round: What It Means for Midi Health**

The $63 million Series B funding round, led by top-tier investors, will enable Midi Health to expand its services and reach more women across the United States. The company plans to use the funds to enhance its digital platform, increase its clinical offerings, and grow its team of healthcare professionals specializing in menopause care. Additionally, the funding will support research and development efforts aimed at improving the understanding of menopause and developing new treatment options.

Midi Health’s CEO, Joanna Strober, expressed her excitement about the funding round and the involvement of high-profile investors like Schumer and Britton. “We are thrilled to have Amy and Connie on board as we work to transform menopause care for women everywhere,” Strober said in a statement. “Their passion for women’s health and their commitment to breaking down barriers make them ideal partners in our mission.”

### **A Growing Market for Women’s Health Tech**

The success of Midi Health’s Series B funding round is part of a broader trend in the healthcare industry, where women’s health tech—often referred to as “femtech”—is gaining traction. According to Frost & Sullivan, the global femtech market is expected to reach $50 billion by 2025, driven by increasing awareness of women’s health issues and the growing demand for personalized healthcare solutions.

Historically, women’s health has been underfunded and under-researched, but companies like Midi Health are changing that narrative. By focusing on menopause, a stage of life that affects nearly half of the population but has received little attention from the medical community, Midi Health is addressing a critical gap in healthcare.

### **The Future of Menopause Care**

As Midi Health continues to grow, it has the potential to set a new standard for menopause care. The company’s digital-first approach allows women to access care from the comfort of their homes, making it easier for those who may not have access to specialized healthcare providers in their local area. By leveraging technology, Midi Health can offer personalized treatment plans based on each

**Talkspace to Join Amazon Health Services Platform: A New Era for Digital Mental Health Care**

In a significant development for the digital health landscape, Talkspace, a leading online therapy platform, is set to join Amazon’s Health Services platform. This collaboration marks a major step forward in expanding access to mental health services, leveraging Amazon’s vast reach and Talkspace’s expertise in teletherapy. The partnership could reshape how millions of people access mental health care, offering convenience, affordability, and privacy through a seamless digital experience.

### The Rise of Digital Mental Health Services

Mental health care has traditionally been limited by geographic, financial, and logistical barriers. In recent years, however, digital health platforms like Talkspace have emerged as a solution to these challenges. Talkspace, founded in 2012, offers therapy and psychiatric services via text, video, and voice messaging, making mental health care more accessible to people who may otherwise struggle to find or afford in-person therapy.

The COVID-19 pandemic accelerated the adoption of telehealth services, with more people turning to online platforms for their mental health needs. According to a report by the American Psychological Association, nearly 75% of psychologists saw an increase in demand for mental health services during the pandemic, with many shifting to teletherapy to meet this demand. Talkspace has been at the forefront of this shift, offering services that are both flexible and affordable.

### Amazon’s Growing Role in Health Care

Amazon’s foray into health care has been a gradual but deliberate process. In 2018, Amazon acquired the online pharmacy PillPack, signaling its intent to enter the health care space. Since then, the company has launched Amazon Pharmacy, offering prescription medications delivered to customers’ doors. In 2021, Amazon introduced Amazon Care, a telehealth service that provides virtual and in-person care for employees and their families. The service has since expanded to other companies, allowing Amazon to extend its health care offerings to a broader audience.

Amazon’s Health Services platform is part of the company’s broader strategy to integrate health care into its ecosystem. By offering a range of services, from prescription medications to telehealth consultations, Amazon aims to simplify the health care experience for its customers. The addition of Talkspace to this platform is a natural extension of Amazon’s efforts to provide comprehensive health care services, including mental health support.

### The Benefits of the Partnership

The collaboration between Talkspace and Amazon Health Services offers several key benefits for consumers:

1. **Increased Accessibility**: Amazon’s vast customer base and logistical infrastructure will make it easier for people to access Talkspace’s mental health services. With millions of people already using Amazon for their daily needs, integrating mental health care into the platform could remove barriers to seeking help.

2. **Convenience**: Amazon’s Health Services platform is designed to offer a seamless experience, allowing users to access a range of health care services from a single platform. By integrating Talkspace, Amazon will enable users to schedule therapy sessions, receive medication, and manage their health care needs all in one place.

3. **Affordability**: One of Talkspace’s key selling points is its affordability compared to traditional in-person therapy. By partnering with Amazon, Talkspace may be able to offer even more competitive pricing, potentially making mental health care more affordable for a larger audience.

4. **Privacy and Security**: Both Amazon and Talkspace have robust privacy and security measures in place to protect users’ health information. This partnership will likely maintain strict adherence to HIPAA (Health Insurance Portability and Accountability Act) regulations, ensuring that users’ mental health data is kept confidential.

5. **Expanded Reach**: Talkspace’s inclusion in Amazon’s platform could help the company reach new demographics, including those who may not have previously considered online therapy. Amazon’s ability to market services to its vast user base could introduce more people to the benefits of digital mental health care.

### Challenges and Considerations

While the partnership between Talkspace and Amazon Health Services presents numerous opportunities, there are also challenges to consider:

1. **Quality of Care**: As with any telehealth service, there are concerns about the quality of care provided through digital platforms. While Talkspace has a network of licensed therapists and psychiatrists, ensuring consistent quality across a large user base will be crucial. Amazon and Talkspace will need to work together to maintain high standards of care.

2. **Digital Divide**: While digital health services can increase accessibility, they may also exacerbate the digital divide. Not everyone has access to reliable internet or digital devices, which could limit the reach of Talkspace’s services. Addressing this issue will be important for ensuring that the partnership benefits all populations.

3. **Competition**: The digital health space is becoming increasingly crowded, with companies like BetterHelp, Cerebral, and Ginger also offering online mental health services. Amazon and Talkspace will need to differentiate themselves in a competitive market, potentially through pricing, convenience, or unique features.

###

**mPulse Health Acquires Zipari to Expand Healthcare Technology Solutions**

In a significant move aimed at enhancing healthcare technology solutions, **mPulse Health**, a leader in conversational AI and digital health engagement, has announced the acquisition of **Zipari**, a company renowned for its customer experience (CX) platform tailored specifically for health insurance payers. This strategic acquisition is poised to create a more comprehensive suite of digital tools that will empower healthcare organizations to improve patient engagement, streamline operations, and ultimately deliver better health outcomes.

### The Companies: mPulse Health and Zipari

**mPulse Health** has built a strong reputation in the healthcare industry by leveraging conversational AI, behavioral science, and data analytics to engage patients through personalized, automated communications. The company’s solutions are designed to drive better health outcomes by encouraging patients to adhere to treatment plans, attend appointments, and make informed decisions about their health. mPulse Health’s platform is widely used by healthcare providers, payers, and pharmaceutical companies to engage patients via SMS, email, voice, and other digital channels.

On the other hand, **Zipari** is a leading provider of customer experience solutions for health insurance payers. The company’s platform is designed to improve member engagement by offering personalized, real-time interactions across multiple touchpoints, including web portals, mobile apps, and customer service channels. Zipari’s technology helps health plans enhance member satisfaction, reduce administrative costs, and improve overall operational efficiency.

### The Strategic Rationale Behind the Acquisition

The acquisition of Zipari by mPulse Health represents a strategic alignment of two complementary companies. While mPulse Health has focused on patient engagement through conversational AI and behavioral science, Zipari has specialized in improving the customer experience for health insurance members. By combining their expertise, the two companies aim to offer a more holistic solution that addresses the needs of both healthcare providers and payers.

Here are some key reasons why this acquisition makes sense:

1. **Enhanced Patient and Member Engagement**: The integration of mPulse Health’s conversational AI with Zipari’s CX platform will enable healthcare organizations to engage patients and health plan members in a more personalized and efficient manner. This could lead to improved adherence to treatment plans, better health outcomes, and higher member satisfaction.

2. **Comprehensive Digital Health Solutions**: The combined capabilities of mPulse Health and Zipari will allow healthcare organizations to offer a more comprehensive suite of digital tools. From appointment reminders and medication adherence to customer service inquiries and claims processing, the new platform will cover a wide range of patient and member needs.

3. **Data-Driven Insights**: Both mPulse Health and Zipari are known for their data analytics capabilities. By merging their data sets and analytical tools, the combined company will be able to offer deeper insights into patient behavior, member preferences, and operational efficiencies. This could help healthcare organizations make more informed decisions and optimize their strategies.

4. **Improved Operational Efficiency**: The acquisition is expected to streamline operations for healthcare organizations by integrating patient engagement and customer experience functions into a single platform. This could reduce administrative costs, improve workflow efficiency, and free up resources for other critical areas of care.

5. **Scalability and Market Reach**: With the acquisition, mPulse Health will be able to expand its market reach, particularly in the health insurance payer space, where Zipari has a strong foothold. This will allow the combined company to scale its solutions more effectively and serve a broader range of healthcare organizations.

### The Impact on Healthcare Providers and Payers

For healthcare providers and payers, the acquisition of Zipari by mPulse Health is likely to bring several benefits:

– **Improved Member Retention**: Health plans often struggle with member retention due to poor customer experiences. By leveraging Zipari’s CX platform in combination with mPulse Health’s engagement tools, health plans can offer a more seamless and personalized experience, which could lead to higher member retention rates.

– **Better Health Outcomes**: Engaging patients and members in their healthcare journey is critical to improving health outcomes. The combined platform will enable healthcare organizations to deliver timely, relevant, and personalized communications that encourage patients to take proactive steps in managing their health.

– **Cost Savings**: By automating routine tasks such as appointment scheduling, medication reminders, and customer service inquiries, healthcare organizations can reduce administrative costs and improve operational efficiency. This is particularly important in an industry where margins are often tight.

– **Regulatory Compliance**: Both mPulse Health and Zipari have experience navigating the complex regulatory landscape of healthcare. The combined platform will continue to prioritize compliance with regulations such as HIPAA, ensuring that patient and member data is handled securely and in accordance with industry standards.

### The Future of Digital Health Engagement

The acquisition of Zipari by mPulse Health is a clear indication of the growing importance of digital engagement in healthcare. As patients and health plan members increasingly expect personalized, convenient, and efficient interactions with their healthcare providers and insurers, organizations must invest in technology that

**Discussion on Reproductive Rights During an Election Cycle: A Q&A with Headspace**

As election cycles roll around, certain issues take center stage in political discourse, and one of the most debated topics is reproductive rights. This issue encompasses a range of concerns, including access to contraception, abortion rights, maternal healthcare, and more. To better understand the complexities of reproductive rights during an election cycle, we sat down with experts from *Headspace*, a leading organization focused on mental health and wellness, to discuss how these issues intersect with mental well-being, political advocacy, and the broader societal landscape.

**Q: Why do reproductive rights become such a hot-button issue during election cycles?**

**Headspace Expert:** Reproductive rights touch on deeply personal and moral beliefs, which makes them inherently polarizing. During election cycles, political candidates often use these issues to galvanize their base, knowing that they can evoke strong emotional responses. For many voters, reproductive rights are not just abstract political concepts but are tied to their personal autonomy, health, and well-being. This makes the topic a powerful tool for mobilizing voters, but it also means the debate can become highly charged and divisive.

**Q: How do discussions around reproductive rights impact mental health, particularly for women and marginalized communities?**

**Headspace Expert:** The ongoing debate around reproductive rights can have significant mental health implications, especially for women, LGBTQ+ individuals, and marginalized communities. When access to reproductive healthcare is threatened or restricted, it can lead to increased stress, anxiety, and feelings of helplessness. For example, women who live in states with restrictive abortion laws may experience heightened anxiety about their ability to make decisions about their own bodies. Additionally, marginalized communities—such as low-income individuals and people of color—are disproportionately affected by these restrictions, which can exacerbate feelings of disenfranchisement and systemic inequality.

At *Headspace*, we emphasize the importance of mental well-being and self-care, especially during periods of political uncertainty. It’s crucial for individuals to find ways to manage stress and anxiety, whether that’s through mindfulness practices, therapy, or community support.

**Q: How do political candidates’ positions on reproductive rights influence voter behavior?**

**Headspace Expert:** Reproductive rights are a key issue for many voters, particularly women and younger generations. Candidates who take a strong stance on either side of the issue can significantly influence voter turnout. For example, candidates who support access to abortion and contraception may attract voters who prioritize bodily autonomy and gender equality. On the other hand, candidates who advocate for more restrictive reproductive policies may appeal to voters with conservative or religious values.

It’s important to note that reproductive rights are often a “litmus test” issue for many voters. In other words, a candidate’s stance on this issue may be a deciding factor in whether or not they receive a voter’s support, regardless of their positions on other issues.

**Q: What role does misinformation play in the reproductive rights debate during election cycles?**

**Headspace Expert:** Misinformation is a significant problem in the reproductive rights debate, particularly during election cycles. Politicians and advocacy groups may spread misleading or false information about abortion, contraception, and reproductive healthcare to sway public opinion. For example, there are persistent myths about the safety of abortion procedures or the effects of contraception that have been debunked by medical professionals, but these myths continue to circulate in political discourse.

Misinformation can lead to confusion and fear, which in turn can affect voters’ decisions at the ballot box. It’s essential for voters to seek out reliable, evidence-based information from trusted sources, such as medical organizations and nonpartisan fact-checkers, to make informed decisions.

**Q: How can individuals advocate for reproductive rights during an election cycle?**

**Headspace Expert:** Advocacy can take many forms, and individuals can engage in the political process in ways that align with their values and capacities. Here are a few ways to advocate for reproductive rights:

1. **Stay Informed:** Knowledge is power. Stay up-to-date on candidates’ positions on reproductive rights and understand the potential impact of proposed policies.

2. **Vote:** Voting is one of the most direct ways to influence policy. Make sure you’re registered to vote, and encourage others to do the same. Research candidates and vote for those who align with your values on reproductive rights.

3. **Contact Elected Officials:** Reach out to your representatives to express your views on reproductive rights. Elected officials are more likely to take action when they hear directly from their constituents.

4. **Support Advocacy Organizations:** There are many organizations that work to protect and expand reproductive rights. Consider donating or volunteering with groups that align with your values.

5. **Engage in Conversations:** While it can be challenging, engaging in respectful conversations with friends, family, and colleagues about reproductive rights can help raise awareness and shift perspectives.

**Q: What advice does Headspace offer for managing stress and

**AI Model for Minor Languages Identifies Depression in Korea: A Breakthrough in Mental Health Diagnostics**

In recent years, artificial intelligence (AI) has made significant strides in various fields, from healthcare to education. One of the most promising applications of AI is in the realm of mental health, where machine learning models are being developed to detect early signs of psychological conditions such as depression. While much of the focus has been on major languages such as English, Chinese, and Spanish, a new AI model designed for minor languages is making waves in South Korea by identifying depression in Korean speakers. This development is particularly significant given the cultural and linguistic nuances that often make mental health diagnostics challenging in non-Western contexts.

### The Mental Health Crisis in South Korea

South Korea has one of the highest suicide rates among developed countries, with depression being a major contributing factor. Despite the prevalence of mental health issues, there is still a strong stigma surrounding mental illness in Korean society. Many individuals are reluctant to seek help due to fear of judgment or social ostracism. Furthermore, the lack of mental health professionals and resources exacerbates the problem, particularly in rural areas where access to care is limited.

Language also plays a crucial role in mental health diagnostics. Korean is a language rich in cultural and emotional subtext, and expressions of distress may not always align with Western diagnostic criteria. For example, Koreans may express psychological pain through physical symptoms, a phenomenon known as “somatization.” This makes it difficult for traditional diagnostic tools, which are often based on Western models, to accurately identify mental health conditions in Korean speakers.

### The Role of AI in Mental Health Diagnostics

AI has the potential to revolutionize mental health diagnostics by analyzing large datasets of language patterns, social media posts, and other forms of communication to detect signs of depression. These models can be trained to recognize subtle linguistic cues that may indicate emotional distress, such as changes in tone, word choice, or sentence structure.

However, most AI models have been trained on data from major languages, limiting their effectiveness in identifying depression in speakers of minor or less commonly studied languages. This is where the new AI model for Korean comes into play.

### The AI Model for Minor Languages

Developed by a team of researchers in South Korea, this AI model is specifically designed to identify depression in Korean speakers. The model was trained on a large dataset of Korean-language texts, including social media posts, blogs, and online forums where individuals discuss their mental health experiences. By analyzing these texts, the AI was able to identify patterns of language use that are associated with depression.

One of the key innovations of this model is its ability to account for the unique linguistic and cultural features of the Korean language. For example, the model is trained to recognize indirect expressions of distress, such as references to physical pain or fatigue, which are common in Korean culture. It also takes into account the use of honorifics and other formal language structures that may influence how individuals express their emotions.

### How the AI Model Works

The AI model uses natural language processing (NLP) techniques to analyze text data. NLP is a branch of AI that focuses on the interaction between computers and human language. In this case, the model was trained to identify specific linguistic markers that are associated with depression, such as:

1. **Negative Sentiment**: The model looks for words and phrases that convey sadness, hopelessness, or despair. It also analyzes the overall tone of the text to determine whether the individual is expressing negative emotions.

2. **Changes in Language Use**: Depressed individuals may exhibit changes in their language patterns, such as using shorter sentences, more first-person pronouns (e.g., “I,” “me”), and fewer positive words. The model is trained to detect these shifts in language use.

3. **Cultural Expressions of Distress**: As mentioned earlier, the model is designed to recognize culturally specific expressions of distress, such as references to physical symptoms or indirect expressions of emotional pain.

Once the model has analyzed a text, it assigns a depression score based on the likelihood that the individual is experiencing depression. This score can then be used by mental health professionals to assess the individual’s mental health and determine whether further intervention is needed.

### Applications and Implications

The AI model has several potential applications in South Korea. One of the most promising is its use in social media monitoring. Many individuals who are struggling with depression may not seek help from a mental health professional, but they may express their feelings online. By analyzing social media posts, the AI model can identify individuals who may be at risk of depression and alert mental health professionals or community organizations.

Another potential application is in telemedicine. With the rise of telehealth services, particularly during the COVID-19 pandemic, AI models like this one could be integrated into online mental health platforms to provide real-time assessments of patients’ mental health. This could be particularly useful in rural areas where access to mental health professionals is limited

**Utilizing Electronic Medical Records (EMR) Data for Personalized Management of Inflammatory Bowel Disease (IBD)**

Inflammatory Bowel Disease (IBD), which primarily includes Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic condition characterized by inflammation of the gastrointestinal tract. The management of IBD is complex due to its heterogeneous nature, with patients experiencing varying symptoms, disease progression, and responses to treatment. As such, personalized management strategies are critical to improving patient outcomes. One of the most promising tools for achieving this is the use of Electronic Medical Records (EMR) data. This article explores how EMR data can be leveraged to enhance the personalized management of IBD, improving both clinical decision-making and patient care.

### The Role of EMR in Healthcare

Electronic Medical Records (EMRs) are digital versions of patients’ paper charts and contain a wealth of information, including medical history, diagnoses, medications, treatment plans, immunization dates, allergies, radiology images, and laboratory test results. EMRs are designed to streamline the documentation process, improve communication between healthcare providers, and enhance the overall quality of care.

However, beyond these administrative and clinical functions, EMRs also serve as a rich repository of data that can be analyzed to identify patterns, predict outcomes, and tailor treatment plans to individual patients. In the context of IBD, EMR data can be used to support personalized management strategies, allowing for more precise, data-driven decision-making.

### Benefits of Using EMR Data for IBD Management

1. **Comprehensive Patient Profiles**
EMRs provide a longitudinal view of a patient’s health, capturing information from multiple healthcare encounters. For IBD patients, this means that clinicians can easily access a detailed history of disease activity, treatment responses, and complications. By analyzing this data, clinicians can identify trends in disease progression and tailor treatment strategies accordingly. For example, if a patient has a history of frequent flare-ups during certain seasons or after specific triggers (e.g., stress or diet changes), this information can be used to develop preventive strategies.

2. **Early Identification of Disease Patterns**
EMRs can help identify early warning signs of disease exacerbation or complications. For instance, by tracking laboratory markers such as C-reactive protein (CRP) or fecal calprotectin levels, clinicians can detect subtle changes that may indicate an impending flare-up. EMR systems can be programmed to flag abnormal results, prompting timely interventions before the patient’s condition worsens. This proactive approach can reduce hospitalizations and improve quality of life for IBD patients.

3. **Personalized Treatment Plans**
IBD treatment often involves a combination of medications, including aminosalicylates, corticosteroids, immunomodulators, and biologics. However, not all patients respond to these treatments in the same way. EMR data can be used to track treatment efficacy and side effects over time, allowing clinicians to adjust therapies based on individual patient responses. For example, if a patient does not respond well to a particular biologic agent, the EMR can provide insights into alternative therapies that have been successful for similar patients.

4. **Predictive Analytics and Machine Learning**
One of the most exciting applications of EMR data is the use of predictive analytics and machine learning algorithms. By analyzing large datasets of IBD patients, machine learning models can be trained to predict disease outcomes, such as the likelihood of a flare-up, the risk of surgery, or the probability of developing complications like fistulas or strictures. These predictive models can help clinicians make more informed decisions about treatment escalation, surgical interventions, and long-term management strategies.

For example, a machine learning model could analyze a patient’s EMR data, including age, disease duration, medication history, and laboratory results, to predict the risk of hospitalization within the next six months. Armed with this information, clinicians can take preventive measures, such as adjusting medications or scheduling more frequent follow-up visits, to reduce the risk of adverse outcomes.

5. **Improved Patient Engagement and Self-Management**
EMRs can also be integrated with patient portals, allowing individuals with IBD to access their health information, track their symptoms, and communicate with their healthcare providers. This increased engagement can empower patients to take a more active role in managing their condition. For example, patients can use the portal to record symptoms such as abdominal pain, diarrhea, or fatigue, and this data can be automatically uploaded to the EMR for review by the healthcare team. This real-time monitoring can help identify patterns and triggers, enabling more personalized and timely interventions.

6. **Facilitating Multidisciplinary Care**
The management of IBD often requires input from a multidisciplinary team, including gastroenterologists, dietitians, surgeons, and mental health professionals. EMRs facilitate communication and coordination among these providers by ensuring that all members of the care team have access to the

# Utilizing Explainable AI to Address Japan’s Increasing Stroke Risk

## Introduction

Japan, known for its high life expectancy and advanced healthcare system, is facing a growing public health challenge: an increasing risk of stroke, particularly among its aging population. Strokes are a leading cause of death and long-term disability in Japan, with the number of cases expected to rise as the population continues to age. According to the World Health Organization (WHO), Japan has one of the highest rates of stroke-related mortality in the developed world, a concerning trend that demands innovative solutions.

One promising approach to addressing this issue is the use of **Explainable Artificial Intelligence (XAI)**. While AI has already made significant strides in healthcare, particularly in predictive analytics and diagnostics, the “black-box” nature of many AI models has raised concerns about transparency and trustworthiness. XAI, which aims to make AI decision-making processes more understandable to humans, offers a way to bridge this gap. By applying XAI to stroke prevention and treatment, Japan can leverage cutting-edge technology while ensuring that healthcare professionals and patients alike can trust and act on AI-driven insights.

## The Growing Stroke Risk in Japan

### Aging Population and Lifestyle Factors

Japan’s population is aging rapidly, with nearly 30% of its citizens aged 65 or older, the highest proportion in the world. Aging is a significant risk factor for stroke, as older adults are more likely to suffer from conditions such as hypertension, diabetes, and atrial fibrillation, all of which increase stroke risk. Additionally, lifestyle factors such as high salt intake, smoking, and physical inactivity further exacerbate the problem.

### Stroke Types and Consequences

Strokes can be broadly classified into two types: **ischemic strokes**, caused by a blockage in blood vessels supplying the brain, and **hemorrhagic strokes**, caused by the rupture of a blood vessel in the brain. Both types can lead to severe consequences, including paralysis, speech difficulties, and cognitive impairments. The economic burden of stroke care is also significant, with long-term rehabilitation and caregiving costs placing a strain on Japan’s healthcare system.

Given the complexity of stroke risk factors and the need for early intervention, there is a growing demand for predictive tools that can help identify individuals at high risk and recommend personalized prevention strategies. This is where AI, and more specifically, Explainable AI, can play a pivotal role.

## The Role of Explainable AI in Stroke Risk Prediction

### Traditional AI vs. Explainable AI

Traditional AI models, such as deep learning algorithms, have shown great promise in predicting stroke risk by analyzing large datasets of patient information, including medical history, lifestyle factors, and genetic data. However, these models often operate as “black boxes,” meaning that while they may provide accurate predictions, the reasoning behind these predictions is not easily understood by humans. This lack of transparency can be problematic in healthcare, where trust and accountability are paramount.

Explainable AI (XAI) seeks to address this issue by making AI models more interpretable. XAI techniques provide insights into how a model arrives at its predictions, allowing healthcare professionals to understand the factors contributing to a patient’s stroke risk. This transparency can improve decision-making, foster trust in AI systems, and ultimately lead to better patient outcomes.

### How XAI Can Help in Stroke Prevention

1. **Personalized Risk Assessment**: XAI can analyze a wide range of data, including medical records, imaging data, and lifestyle information, to provide a personalized stroke risk score for each patient. Importantly, XAI can explain which factors—such as high blood pressure, cholesterol levels, or smoking habits—are contributing the most to an individual’s risk. This allows healthcare providers to tailor prevention strategies to each patient’s unique needs.

2. **Early Detection of High-Risk Patients**: By identifying patterns in patient data that may not be immediately obvious to human clinicians, XAI can help detect early warning signs of stroke risk. For example, subtle changes in blood pressure or heart rate variability might indicate an increased risk of stroke, even in patients who appear healthy. XAI can highlight these patterns and explain the reasoning behind its predictions, enabling earlier interventions.

3. **Improved Patient-Doctor Communication**: One of the key advantages of XAI is its ability to facilitate better communication between doctors and patients. When patients understand why they are at risk for a stroke, they are more likely to adhere to recommended lifestyle changes or treatments. XAI can provide visualizations and explanations that make complex medical data more accessible to patients, helping them take an active role in their own healthcare.

4. **Optimizing Treatment Plans**: In the event that a patient does suffer a stroke, XAI can assist in determining the most effective treatment plan. For example, XAI can analyze imaging data to predict the likelihood of a patient responding to certain treatments, such as clot-busting drugs or surgical interventions. By explaining the factors influencing these predictions,

**General Catalyst Establishes Institute Aimed at Enhancing Global Resilience Through Innovation**

In an era marked by rapid technological advancements, geopolitical instability, and unprecedented global challenges such as climate change and pandemics, the need for enhanced resilience has never been more critical. Recognizing this, General Catalyst, a prominent venture capital firm, has launched a new initiative — the General Catalyst Institute for Global Resilience. The institute is designed to foster innovation and collaboration across sectors to address some of the most pressing issues facing humanity today.

### The Vision Behind the Institute

The General Catalyst Institute for Global Resilience aims to be a hub for thought leadership, research, and the development of cutting-edge solutions to bolster resilience on a global scale. The institute’s mission is to bring together experts from various fields, including technology, healthcare, finance, and public policy, to create innovative solutions that can withstand and adapt to future crises.

The institute’s core focus is on building resilience in three key areas:

1. **Climate Resilience**: As climate change continues to disrupt ecosystems, economies, and communities, the institute will focus on developing technologies and strategies that can mitigate the effects of climate change. This includes innovations in renewable energy, sustainable agriculture, and disaster preparedness.

2. **Healthcare Resilience**: The COVID-19 pandemic exposed vulnerabilities in global healthcare systems. The institute will work on strengthening healthcare infrastructure, improving access to care, and developing new technologies that can prevent, detect, and respond to future pandemics and health crises.

3. **Economic Resilience**: Economic shocks, whether caused by natural disasters, pandemics, or geopolitical tensions, can have far-reaching consequences. The institute will explore ways to build more resilient economies through innovations in financial technology, supply chain management, and workforce development.

### A Collaborative Approach

One of the defining features of the General Catalyst Institute for Global Resilience is its collaborative approach. The institute will partner with governments, non-governmental organizations (NGOs), academic institutions, and private sector companies to ensure that its initiatives are grounded in real-world needs and have a broad impact.

By fostering collaboration across sectors, the institute aims to break down silos and encourage the sharing of knowledge and resources. This collaborative model is essential for addressing complex, interconnected challenges that no single organization or sector can solve alone.

### Leveraging Technology for Resilience

At the heart of the institute’s work is the belief that technology can be a powerful tool for enhancing resilience. General Catalyst has a long history of investing in innovative companies that are using technology to solve big problems, and the institute will build on this legacy.

For example, the institute may support the development of artificial intelligence (AI) and machine learning tools that can predict and respond to natural disasters more effectively. It may also explore the use of blockchain technology to create more transparent and resilient supply chains, or invest in biotech startups working on next-generation vaccines and treatments.

By leveraging the latest advancements in technology, the institute hopes to create solutions that are not only effective but also scalable and sustainable.

### A Focus on Equity and Inclusion

While the institute is focused on innovation, it is also committed to ensuring that the benefits of its work are shared equitably. Global resilience cannot be achieved if certain communities are left behind, and the institute will prioritize initiatives that promote inclusion and address disparities in access to resources and opportunities.

This commitment to equity is particularly important in the context of climate change and healthcare, where vulnerable populations are often the hardest hit. The institute will work to ensure that its solutions are accessible to all, regardless of geography or socioeconomic status.

### Measuring Impact

To ensure that its initiatives are making a meaningful difference, the General Catalyst Institute for Global Resilience will implement a robust system for measuring impact. This will include both quantitative metrics, such as the number of people reached or the amount of carbon emissions reduced, as well as qualitative assessments of how its initiatives are improving resilience on the ground.

The institute will also prioritize transparency and accountability, regularly publishing reports on its progress and engaging with stakeholders to gather feedback and refine its approach.

### Looking Ahead

The establishment of the General Catalyst Institute for Global Resilience comes at a time when the world is facing unprecedented challenges, but also unprecedented opportunities for innovation. By bringing together the brightest minds from across sectors and leveraging the power of technology, the institute aims to create a more resilient, equitable, and sustainable future for all.

As the institute begins its work, it will undoubtedly face challenges of its own. Building global resilience is a complex and ongoing process, and there are no easy solutions. However, with its collaborative approach, commitment to innovation, and focus on equity, the General Catalyst Institute for Global Resilience is well-positioned to make a significant impact.

In the years to come, the institute’s work could serve as a model for how businesses, governments, and civil society can come together to address the world’s most pressing challenges and build a more resilient global community.

### Conclusion

The General Catalyst Institute for

# A Comprehensive Guide to the World’s Most Popular Cookies

Cookies are a universal treat, beloved by people of all ages and cultures. Whether they are soft and chewy or crisp and crunchy, cookies come in a wide variety of flavors, shapes, and textures. From the classic chocolate chip to the delicate French macaron, cookies have become a global phenomenon, with each country contributing its own unique twist to this beloved dessert. In this guide, we’ll take you on a journey around the world to explore the most popular cookies, their origins, and what makes them so special.

## 1. **Chocolate Chip Cookies (USA)**

### Origin:
The chocolate chip cookie is arguably the most iconic cookie in the world. It was invented in the 1930s by Ruth Wakefield, who ran the Toll House Inn in Massachusetts. The story goes that she added chopped-up pieces of a Nestlé chocolate bar to her cookie dough, expecting them to melt, but instead, they held their shape, creating the first chocolate chip cookie.

### Characteristics:
– **Texture:** Soft and chewy with a slightly crisp edge.
– **Flavor:** Sweet, buttery, and rich with chocolate.
– **Ingredients:** Flour, sugar, butter, eggs, vanilla extract, and chocolate chips.

### Fun Fact:
The original recipe became so popular that Nestlé made a deal with Wakefield to print her recipe on their chocolate bar packaging in exchange for a lifetime supply of chocolate.

## 2. **Macarons (France)**

### Origin:
Macarons are delicate, meringue-based cookies that originated in Italy but were popularized in France. They were brought to France by Catherine de’ Medici in the 16th century, but it wasn’t until the 20th century that the modern macaron, with its signature filling, became a Parisian staple.

### Characteristics:
– **Texture:** Crisp on the outside, soft and chewy on the inside.
– **Flavor:** Sweet with a variety of fillings like buttercream, ganache, or jam.
– **Ingredients:** Almond flour, egg whites, powdered sugar, and food coloring.

### Fun Fact:
Macarons are notoriously difficult to make due to their delicate structure and the precision required in baking. Ladurée, a famous French patisserie, is known for popularizing the modern macaron.

## 3. **Biscotti (Italy)**

### Origin:
Biscotti, also known as “cantucci,” originated in the Tuscan region of Italy. The word “biscotti” means “twice-baked,” which refers to the baking process that gives these cookies their signature crunch. Historically, biscotti were a staple for Roman soldiers because of their long shelf life.

### Characteristics:
– **Texture:** Hard and crunchy.
– **Flavor:** Slightly sweet with hints of almond or anise.
– **Ingredients:** Flour, sugar, eggs, almonds, and sometimes anise or citrus zest.

### Fun Fact:
Biscotti are traditionally dunked in Vin Santo, a sweet Italian dessert wine, or coffee to soften them before eating.

## 4. **Gingersnaps (Sweden)**

### Origin:
Gingersnaps, or “pepparkakor” in Swedish, are spiced cookies that have been enjoyed in Sweden since the 13th century. They were originally made with honey and spices that were believed to have medicinal properties.

### Characteristics:
– **Texture:** Crisp and snappy.
– **Flavor:** Spicy and sweet, with a strong ginger flavor.
– **Ingredients:** Flour, sugar, molasses, ginger, cinnamon, cloves, and sometimes cardamom.

### Fun Fact:
In Sweden, it’s a tradition to make a wish before eating a gingersnap. You place the cookie in your palm, press down with your finger, and if it breaks into three pieces, your wish will come true.

## 5. **Fortune Cookies (China/USA)**

### Origin:
Despite their association with Chinese cuisine, fortune cookies were actually invented in the United States, most likely in California during the early 20th century. They were inspired by Japanese senbei (rice crackers) and adapted to include a small paper fortune inside.

### Characteristics:
– **Texture:** Crisp and light.
– **Flavor:** Mildly sweet with a hint of vanilla.
– **Ingredients:** Flour, sugar, vanilla, and sesame oil.

### Fun Fact:
Fortune cookies are often served at the end of a meal in Chinese-American restaurants, but they are rarely found in China itself.

## 6. **Shortbread (Scotland)**

### Origin:
Shortbread is a traditional Scottish cookie that dates back to the 12th century. It was originally made with leftover bread dough, which was sweetened and baked. Over time, the recipe evolved into the rich, buttery cookie we know today.

### Characteristics:
– **Texture:** Cr

**Amino Health and Motive Practicing Wisely Introduce New Strategy to Improve ACO Performance**

In the ever-evolving landscape of healthcare, Accountable Care Organizations (ACOs) have emerged as a key model for improving patient outcomes while controlling costs. ACOs are groups of doctors, hospitals, and other healthcare providers that come together voluntarily to provide coordinated, high-quality care to Medicare patients. The goal of ACOs is to ensure that patients, especially the chronically ill, receive the right care at the right time, while avoiding unnecessary duplication of services and preventing medical errors.

However, achieving these goals is no small feat. ACOs face numerous challenges, including managing patient populations, reducing healthcare costs, and improving health outcomes. To address these challenges, innovative solutions are needed. Enter **Amino Health** and **Motive Practicing Wisely**, two organizations that have recently introduced a new strategy aimed at improving ACO performance.

### The Role of Amino Health

Amino Health is a healthcare navigation platform that leverages data to help patients find high-quality, cost-effective care. By providing patients with personalized recommendations for healthcare providers and services, Amino Health empowers individuals to make informed decisions about their care. The platform uses a combination of claims data, provider quality metrics, and patient reviews to guide patients toward the best possible care options.

For ACOs, Amino Health offers a powerful tool for improving patient engagement and care coordination. By helping patients find the right providers and services, Amino Health can reduce unnecessary healthcare utilization, such as emergency room visits and hospital readmissions, which are key drivers of healthcare costs. Additionally, the platform’s data-driven approach can help ACOs identify high-performing providers and optimize their networks for better patient outcomes.

### The Role of Motive Practicing Wisely

Motive Practicing Wisely is an organization focused on promoting evidence-based medicine and reducing unnecessary medical interventions. Through its “Practicing Wisely” initiative, Motive works with healthcare providers to encourage the use of clinical guidelines and best practices that prioritize patient safety and cost-effectiveness.

One of the key challenges ACOs face is reducing the overuse of low-value care—tests, treatments, and procedures that provide little to no benefit to patients and may even cause harm. Motive Practicing Wisely addresses this issue by providing ACOs with tools and resources to educate providers about evidence-based practices and encourage more judicious use of healthcare services.

By promoting the use of high-value care and reducing unnecessary interventions, Motive Practicing Wisely can help ACOs improve patient outcomes while controlling costs. This approach aligns with the goals of ACOs, which are incentivized to provide high-quality care while reducing overall healthcare spending.

### The New Strategy: A Collaborative Approach

Amino Health and Motive Practicing Wisely have joined forces to introduce a new strategy aimed at improving ACO performance. This strategy combines Amino Health’s patient navigation platform with Motive Practicing Wisely’s evidence-based care initiatives to create a comprehensive solution for ACOs.

The strategy focuses on three key areas:

1. **Patient Engagement and Navigation**: Amino Health’s platform will be used to help ACO patients find high-quality, cost-effective care. By providing personalized recommendations based on data, the platform can guide patients toward providers who deliver the best outcomes at the lowest cost. This will help ACOs reduce unnecessary healthcare utilization and improve patient satisfaction.

2. **Provider Education and Support**: Motive Practicing Wisely will work with ACO providers to promote the use of evidence-based medicine and reduce the overuse of low-value care. Through educational resources, clinical guidelines, and decision-support tools, providers will be empowered to make more informed decisions about patient care. This will lead to better health outcomes and lower costs for ACOs.

3. **Data-Driven Insights**: Both organizations will leverage data to provide ACOs with actionable insights into their performance. By analyzing claims data, provider quality metrics, and patient outcomes, ACOs will be able to identify areas for improvement and optimize their care delivery models. This data-driven approach will help ACOs achieve their goals of improving care quality while reducing costs.

### The Impact on ACO Performance

The collaboration between Amino Health and Motive Practicing Wisely has the potential to significantly improve ACO performance in several ways:

– **Improved Care Coordination**: By helping patients find the right providers and services, Amino Health’s platform can improve care coordination and reduce fragmentation in the healthcare system. This is especially important for ACOs, which are responsible for managing the care of large patient populations.

– **Reduced Healthcare Costs**: By promoting the use of high-value care and reducing unnecessary interventions, the new strategy can help ACOs control healthcare costs. This is critical for ACOs, which are incentivized to reduce spending while maintaining high-quality care.

– **Better